Scientific & Clinical Publications & Presentations

MenaINV a novel therapeutic target for prevention and treatment of metastatic disease

2018 AACR Cancer Dormancy and Residual Disease Poster - -

A metastasis biomarker (MetaSite Breast Score) is associated with distant recurrence in hormone receptor-positive, HER2-negative early-stage breast cancer

2017 - npj Breast Cancer - Sparano et al.

Neoadjuvant chemoterapy induces breast cancer metastasis through TMEM-mediated mechanism

2017 - Science Translational Medicine - Karagiannis et al.

Mena confers resistance to Paclitaxel in triple-negative breast cancer

2017 - Molecular Cancer Therapeutics - Oudin et al.

Paclitaxel caused a significant increase in the expression of MenaINV at both the gene and protein levels which is associated with increased circulating-tumor cells and cancer cell metastasis. This phenotype is reversed in Mena-null mice with or with treatment with paclitaxel.

2017 - AACR Annual Meeting Abstract - Karagiannis et al.

MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis

2016 - Molecular Biology of the Cell - Oudin et al.

Tumor Cell–Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

2016 - Cancer Discovery - Oudin et al.

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

2016 - Cancer Discovery - Miller et al.

Characterization of the expression of the pro-metastatic MenaINV isoform during breast tumor progression

2016 - Clinical Experimental Metastasis - Oudin et al.

Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer

2015 - BMC Cancer - Forse et al.

PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena

2015 - Molecular Biology of the Cell - Hughes et al.

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

2015 - Cancer Discovery - Harney et al.

Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration

2014 - Science Signaling - Pignatelli et al.

Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer

2014 - Journal of the National Cancer Institute - Rohan et al.

Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors

2013 - IntraVital - Patsialou et al.

Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients

2012 - Breast Cancer Research - Patsialou et al.

Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer

2012 - Breast Cancer Research - Argawal et al.

Mena binds α5 integrin directly and modulates α5β1 function

2012 - The Journal of Cell Biology - Gupton et al.

Correlated Immunohistochemical and Cytological Assays for the Prediction of Hematogenous Dissemination of Breast Cancer

2012 - Journal of Histochemistry & Cytochemistry - Oktay et al.

An EMT-Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

2011 - Plos Genetics - Shapiro et al.

Metastasis: tumor cells becoming MENAcing

2011 - Trends in Cell Biology - Condeelis & Gertler

Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer

2011 - Journal of Cell Science - Roussos et al.

Mena invasive (MenaINV) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM

2011 - Clinical Experimental Metastasis - Roussos et al.

Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors

2010 - Breast Cancer Research - Roussos et al.

Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo

2009 - Clinical Experimental Metastasis - Goswami et al.

Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination

2009 - Clinical Cancer Research - Robinson et al.

In Vivo Assay for Tumor Cell Invasion

2009 - Methods in Molecular Biology - Hernandez et al.

A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis

2008 - Developmental Cell - Philippar et al.

Intravital imaging of metastatic behavior through a mammary imaging window

2008 - Nature Methods - Kedrin et al.

Coordinated Regulation of Pathways for Enhanced Cell Motility and Chemotaxis Is Conserved in Rat and Mouse Mammary Tumors

2007 - Cancer Research - Wang et al.

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

2007 - Cancer Research - Wyckoff et al.

Molecular Cloning of hMena (ENAH) and Its Splice Variant hMena+11a: Epidermal Growth Factor Increases Their Expression and Stimulates hMena+11a Phosphorylation in Breast Cancer Cell Lines

2007 - Cancer Research - Di Modungo et al.

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

2006 - Cell - Condeelis & Pollard

The Great Escape: WhenCancer Cells Hijack the Genes for Chemotaxis and Motility

2005 - Annual Review of Cell and Developmental Biology - Condeelis, Singer & Segall

Tumor cells caught in the act of invading: their strategy for enhanced cell motility

2005 - Trends in Cell Biology - Wang et al.

A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

2004 - Cancer Research - Wyckoff et al.

Human Mena Protein, a Serex Defined Antigen Overexpressed in Breast Cancer Eliciting Both Humoral and CD8 T-Cell Immune Response

2004 - International Journal of Cancer - Di Modungo et al.

Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors

2004 - Cancer Research - Wang et al.

Intravital Imaging of Cell Movement in Tumours

2003 - Nature Reviews Cancer - Condeelis & Segall

Gene expression analysis on small numbers of invasive cells collected by chemotaxis from primary mammary tumors of the mouse

2003 - BMC Biotechnology - Wang et al.